The Lab
Deep-dive research breakdowns, compound profiles, and wellness guides — published since late 2025. Sol explains the science so you can make informed decisions about your health.
Featured Research
Peptides for Healing & Recovery: A Tissue-by-Tissue Research Guide
The honest research picture on peptides for healing — BPC-157, TB-500, GHK-Cu, and collagen peptides by tissue type: tendons, ligaments, muscle, bone, joints, and what the evidence actually supports.
CagriSema: REDEFINE Data, the REIMAGINE 2 T2D Win, and Where the Compound Lands
CagriSema combines cagrilintide and semaglutide — what REIMAGINE 2 showed in type 2 diabetes, why REDEFINE 4 missed against Zepbound, and where the compound actually stands.
Semaglutide: STEP Trials, SELECT Cardiovascular Outcomes, and the Compounding Landscape
The semaglutide research picture — STEP trial weight loss data, SELECT cardiovascular outcomes, side effects, muscle loss, and what happened to the compounding landscape.
GLP-1 Peptides: The Complete Class Guide
The GLP-1 peptide class explained — how incretins work, what defines the class today, and how semaglutide, tirzepatide, retatrutide, and CagriSema compare.
NAD+: The Complete Guide to the Molecule at the Center of Aging Research
A comprehensive look at NAD+ biology — sirtuins, PARPs, CD38, delivery routes, the precursor debate, and an honest assessment of the human evidence.
Retatrutide vs Tirzepatide: How the Triple Agonist Compares to the Current Standard
Retatrutide adds glucagon receptor activation to the GLP-1/GIP base — how the triple agonist Phase 2 data compares to tirzepatide and what Phase 3 needs to confirm.
Tirzepatide vs Semaglutide: The SURMOUNT-5 Head-to-Head and What It Settled
The first head-to-head trial of tirzepatide vs semaglutide — SURMOUNT-5 data (NEJM 2025), Mounjaro vs Zepbound, the GIP receptor debate, and side effects compared.
GHK-Cu: 4,000 Genes, Copper Biology, and Why This Peptide Keeps Surprising Researchers
GHK-Cu complete guide — from Loren Pickart's 1973 discovery to the 4,000-gene activation data. Collagen, wound healing, and hair growth research.
BPC-157: The Complete Guide to the Body Protection Compound
The most-researched tissue repair peptide — BPC-157 mechanisms, Zagreb studies, oral vs injectable, the cancer debate, and the 2026 FDA pivot.
What Are Peptides? A Science-First Primer
What peptides are, how they work, the difference between FDA-approved drugs and research-stage compounds, and where the 2026 regulatory pivot leaves things.
All Articles
Peptides for Joint Pain: What the Research Actually Shows
The evidence on peptides for joint pain is mostly preclinical. What we actually know about BPC-157, TB-500, GHK-Cu, and collagen peptides — and where the research falls short.
Peptides for Healing & Recovery: A Tissue-by-Tissue Research Guide
The honest research picture on peptides for healing — BPC-157, TB-500, GHK-Cu, and collagen peptides by tissue type: tendons, ligaments, muscle, bone, joints, and what the evidence actually supports.
CagriSema: REDEFINE Data, the REIMAGINE 2 T2D Win, and Where the Compound Lands
CagriSema combines cagrilintide and semaglutide — what REIMAGINE 2 showed in type 2 diabetes, why REDEFINE 4 missed against Zepbound, and where the compound actually stands.
Semaglutide: STEP Trials, SELECT Cardiovascular Outcomes, and the Compounding Landscape
The semaglutide research picture — STEP trial weight loss data, SELECT cardiovascular outcomes, side effects, muscle loss, and what happened to the compounding landscape.
SS-31: Targeting the Mitochondrial Membrane — A New Approach to Cellular Aging
How a mitochondria-targeted peptide stabilizes cardiolipin, protects electron transport, and opens a new front in longevity research.
5-Amino-1MQ: A Completely Different Approach to Fat Metabolism
How inhibiting the NNMT enzyme shifts fat cells from storage mode to energy expenditure — without suppressing appetite or requiring injection.
PT-141: What the Research Shows About Melanocortin-Based Sexual Health
PT-141 (bremelanotide) works through the brain, not blood flow — a deep dive into the melanocortin receptor mechanism, clinical data, and what makes it unique.
AOD-9604: The HGH Fragment Approach to Fat Loss
AOD-9604 mimics the fat-burning fragment of growth hormone without the side effects — what the Australian trials showed and how it compares to GLP-1 agonists.
Epitalon: Telomerase Activation and the Science of Biological Aging
Epitalon activates telomerase to maintain telomere length — what decades of research show, where the gaps are, and why longevity researchers watch.
GLP-1 Peptides: The Complete Class Guide
The GLP-1 peptide class explained — how incretins work, what defines the class today, and how semaglutide, tirzepatide, retatrutide, and CagriSema compare.
MOTS-c: The Mitochondrial Peptide Rewriting Metabolic Science
A mitochondrial-derived peptide that mimics exercise at the cellular level — the research behind MOTS-c, how it works, and what it means for metabolic health.
Selank: The Anxiolytic Peptide That Doesn't Sedate
How a synthetic tufsin fragment modulates GABA and BDNF to reduce anxiety without the sedation, tolerance, or dependence issues of traditional anxiolytics.
Semax: BDNF, Neuroplasticity, and the Science of Cognitive Enhancement
An ACTH fragment approved in Russia for stroke recovery is gaining attention as a nootropic. Here is what the research shows about BDNF, NGF, and cognition.
CJC-1295 Without DAC: Why Pulsatile GH Release Matters
Modified GRF(1-29) preserves natural growth hormone pulsatility instead of sustained elevation. Here is why that distinction matters for researchers.
Melanotan II: Melanin, Libido, and an Honest Look at the Risk Profile
Melanotan II activates multiple melanocortin receptors with effects on skin pigmentation, appetite, and libido. Here is a balanced look at the evidence.
HCG: Fertility Preservation, Testosterone Support, and What the Evidence Shows
HCG mimics luteinizing hormone to maintain testicular function during TRT and support fertility. A research-grounded guide to the evidence and applications.
NAD+: The Complete Guide to the Molecule at the Center of Aging Research
A comprehensive look at NAD+ biology — sirtuins, PARPs, CD38, delivery routes, the precursor debate, and an honest assessment of the human evidence.
Retatrutide vs Tirzepatide: How the Triple Agonist Compares to the Current Standard
Retatrutide adds glucagon receptor activation to the GLP-1/GIP base — how the triple agonist Phase 2 data compares to tirzepatide and what Phase 3 needs to confirm.
Tirzepatide vs Semaglutide: The SURMOUNT-5 Head-to-Head and What It Settled
The first head-to-head trial of tirzepatide vs semaglutide — SURMOUNT-5 data (NEJM 2025), Mounjaro vs Zepbound, the GIP receptor debate, and side effects compared.
GHK-Cu: 4,000 Genes, Copper Biology, and Why This Peptide Keeps Surprising Researchers
GHK-Cu complete guide — from Loren Pickart's 1973 discovery to the 4,000-gene activation data. Collagen, wound healing, and hair growth research.
TB-500: Cell Migration, Tissue Repair, and the Science of Thymosin Beta-4
The complete guide to TB-500 — how Thymosin Beta-4 drives cell migration through actin biology, and what the research says about tissue repair.
BPC-157: The Complete Guide to the Body Protection Compound
The most-researched tissue repair peptide — BPC-157 mechanisms, Zagreb studies, oral vs injectable, the cancer debate, and the 2026 FDA pivot.
GHK-CU: The Copper Peptide Your Skin Already Knows
How a naturally occurring tripeptide activates 4,000+ genes for tissue repair, and why the skin science community is paying attention.
Glutathione: The Antioxidant Your Cells Actually Make
Glutathione is the body's primary antioxidant — produced in every cell, critical for detoxification. Why it declines with age and what the research shows.
Understanding Your Growth Hormone System
How the growth hormone axis works — pituitary signaling, GHRH, ghrelin receptors, and IGF-1 explained. Why GH declines 14% per decade and what that means.
Sermorelin vs. HGH: What the Research Actually Compares
The pulsatile physiology of Sermorelin against direct HGH replacement — clinical differences, feedback loops, and what the evidence says about each approach.
The Science of Peptide Stacking
What peptide stacking actually means — the CJC-1295 + Ipamorelin GHRH/GHRP synergy, the Wolverine Stack (BPC-157 + TB-500 + GHK-Cu), and why complementary mechanisms outperform single compounds.
Collagen, Elastin, and Why Your Skin Forgets How to Repair
The biology of skin aging: why collagen and elastin decline after 25, what fibroblast slowdown means, and what the research shows about reversing it.
What Are Peptides? A Science-First Primer
What peptides are, how they work, the difference between FDA-approved drugs and research-stage compounds, and where the 2026 regulatory pivot leaves things.