Ipamorelin
Clean GH Secretagogue
Best For
Clean GH support, sleep optimization, lean mass protocols
Clean
No cortisol or prolactin spike
GHRP
GH pulse studied when stacked with GHRH
30 min
Peak GH pulse after administration
How It Works
Ipamorelin is a selective growth hormone secretagogue that binds to ghrelin receptors (GHS-R) on pituitary cells. What makes it exceptional is its selectivity — it triggers GH release without raising cortisol, prolactin, or aldosterone. This clean signal makes it the preferred GHRP for stacking with GHRH analogues like CJC-1295 or Sermorelin.
Key Research Areas
Selective GH Release
No cortisol or prolactin elevation
Stackable
Ideal partner for GHRH analogues — synergistic pulses
Sleep Optimization
Enhances deep sleep when dosed before bed
Recovery
Supports tissue repair and exercise recovery
Research Highlights
- Selective GH release with no cortisol or prolactin elevation
- Ideal for stacking with GHRH analogues for synergistic pulses
Featured Research
Formulation Notes
Common concentrations referenced in published clinical studies:
[IP10]10mgCategory
Growth hormone naturally declines ~14% per decade after age 30. GH secretagogues and GHRH analogues stimulate the pituit...
Explore Renew category →Educational Content. This compound profile is for informational purposes only. Not intended as medical advice, diagnosis, or treatment.
Related Compounds
Sermorelin Acetate
GHRH(1-29) Analogue
- Stimulates natural, pulsatile GH release — not suppressive
- Improves sleep, body composition, and skin within 3-6 months
Reference Codes
[SMO10]10mgCJC-1295 WO/DAC
Short-Acting GHRH
- Mimics body's natural 30-minute GH pulse pattern
- Ideal stacking partner for Ipamorelin — synergistic release
Reference Codes
[CND5]5mg[CND10]10mgCJC-1295 + Ipamorelin
GHRH + GHRP Combination
- Pre-combined GHRH + GHRP for maximum GH synergy
- Clean signal — no cortisol or prolactin elevation
Reference Codes
[CP10]10mg (5+5)Evidence reviewed: March 2026