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Epitalon (Epithalon)

Telomerase Activator Tetrapeptide

Best For

Longevity protocols, circadian rhythm restoration, cellular aging intervention

33%

Extension of cell replicative lifespan in Khavinson studies

4aa

Tetrapeptide — one of the smallest bioregulators studied

20yr

Span of Khavinson's clinical research on epithalamin/epitalon

How It Works

Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that activates telomerase — the ribonucleoprotein enzyme responsible for maintaining telomere length at chromosome ends. Developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology, it acts on the pineal gland to restore melatonin secretion patterns that decline with age. By upregulating hTERT (human telomerase reverse transcriptase) expression, Epitalon enables continued cell division past the Hayflick limit, and its pineal effects normalize circadian rhythm and improve endogenous antioxidant capacity.

Key Research Areas

Telomere Maintenance

Activates telomerase to preserve chromosomal integrity during cell division

Pineal Restoration

Normalizes melatonin synthesis and circadian rhythm regulation

Cellular Longevity

Extends replicative capacity of human somatic cells in vitro by 33%

Antioxidant Support

Upregulates SOD and glutathione pathways via pineal-mediated signaling

Research Highlights

Backed by over two decades of research from the St. Petersburg Institute of Bioregulation
One of the few compounds shown to activate telomerase in human somatic cells

Featured Research

Epitalon: Telomerase Activation and the Science of Biological Aging

Read Sol's deep dive →

Formulation Notes

Common concentrations referenced in published clinical studies:

[ET10]10mg[ET50]50mg

Related Compounds

Recharge

NAD+

Longevity Coenzyme

Powers cellular energy, sirtuin activation, DNA repair
~50% decline by age 50 — restoration supports all function

Reference Codes

[NJ500]500mg

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MOTS-c

Mitochondrial-Derived Signaling Peptide

First mitochondrial-derived peptide shown to translocate to the nucleus and regulate gene expression
Identified by the Lee Lab at USC — a leading center for mitochondrial peptide research

Reference Codes

[MS10]10mg[MS40]40mg

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SS-31 (Elamipretide)

Mitochondrial Membrane Protector

One of the only peptides that targets mitochondrial membranes directly
Reduces ROS at the source rather than scavenging downstream free radicals

Reference Codes

[2S10]10mg[2S50]50mg

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Evidence reviewed: March 2026