NAD+
Longevity Coenzyme
Best For
Anti-aging, energy optimization, cognitive support
50%
Decline in NAD+ levels by age 50
Sirtuin
NAD+-dependent longevity enzymes
PARP
DNA repair enzyme activation
How It Works
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell. It is essential for mitochondrial ATP production, serves as a substrate for sirtuin longevity enzymes (SIRT1-7), and is required by PARP enzymes for DNA repair. NAD+ levels decline approximately 50% by age 50, which is associated with mitochondrial dysfunction, impaired DNA repair, and accelerated aging.
Key Research Areas
Cellular Energy
Rate-limiting for mitochondrial ATP production
DNA Repair
Required substrate for PARP repair enzymes
Sirtuin Activation
Powers SIRT1-7 longevity enzyme family
Cognitive Support
Supports neuronal energy and neuroprotection
Research Highlights
- Powers cellular energy, sirtuin activation, DNA repair
- ~50% decline by age 50 — restoration supports all function
Featured Research
Formulation Notes
Common concentrations referenced in published clinical studies:
[NJ500]500mgCategory
NAD+ is the most critical coenzyme in metabolism — powering every cell's energy and essential for DNA repair. By 50, NAD...
Explore Recharge category →Educational Content. This compound profile is for informational purposes only. Not intended as medical advice, diagnosis, or treatment.
Related Compounds
Glutathione
Master Antioxidant
- Primary endogenous antioxidant involved in liver detoxification
- Essential for mitochondrial function and immune cell support
Reference Codes
[GTT]1500mgLipo-C with B12
Lipotropic Complex
- Methionine, inositol, choline + B12 for fat metabolism
- Complements any metabolic protocol
Reference Codes
[LC216]10mlMOTS-c
Mitochondrial-Derived Signaling Peptide
- First mitochondrial-derived peptide shown to translocate to the nucleus and regulate gene expression
- Identified by the Lee Lab at USC — a leading center for mitochondrial peptide research
Reference Codes
[MS10]10mg[MS40]40mgSolira Peptides carries pharmaceutical-grade NAD+.
View product →Evidence reviewed: March 2026